9-Methyl-β-carboline (9-Me-BC) is a heterocyclic amine of the β-carboline family and is a synthetic research chemical. It is a methylated derivative of β-carboline. The chemical structure of 9-Me-BC consists of a β-carboline core and a methyl group attached to the 9 position of the pyridinium[3,4-b]indole ring system. 9-Me-BC does not appear to have any known natural sources. 9-Me-BC enhances cognition through multiple mechanisms. It upregulates tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, leading to increased dopamine levels. 9-Me-BC also inhibits monoamine oxidase (MAO) activity, preventing the breakdown of dopamine and other monoamine neurotransmitters. In addition, 9-Me-BC stimulates astrocytes to express neurotrophic factors, promoting neuronal growth and survival. In healthy individuals, 9-Me-BC may improve cognition by optimizing neurotransmitter levels and supporting neuronal growth. This may improve memory, attention, and learning. The compound’s ability to increase BDNF and NGF levels may also aid in long-term cognitive health, making 9-Me-BC a popular choice for those seeking to improve mental performance and prevent cognitive decline.